Increased interleukin 5 production in eosinophilic Sézary syndrome: regulation by interferon alfa and interleukin 12
KR Suchin, M Cassin, SL Gottleib, S Sood… - Journal of the American …, 2001 - Elsevier
Background: Peripheral eosinophilia occurs in a small subpopulation of patients with
cutaneous T-cell lymphoma (CTCL) and denotes a poor prognosis. Clinical studies have
suggested that the Sézary cell is a TH2 type helper T cell that produces cytokines that
enhance the differentiation and activation of eosinophils. Interferon alfa (IFN-α) and
interleukin 12 are effective therapeutic agents for CTCL and other hematologic disorders.
Objective: Our purpose was to determine the inhibitory activity of IFN-α and IL-12 on IL-5 …
cutaneous T-cell lymphoma (CTCL) and denotes a poor prognosis. Clinical studies have
suggested that the Sézary cell is a TH2 type helper T cell that produces cytokines that
enhance the differentiation and activation of eosinophils. Interferon alfa (IFN-α) and
interleukin 12 are effective therapeutic agents for CTCL and other hematologic disorders.
Objective: Our purpose was to determine the inhibitory activity of IFN-α and IL-12 on IL-5 …