[HTML][HTML] p16INK4a is selectively silenced in the tumoral progression of mycosis fungoides

IC Navas, P Algara, M Mateo, P Martínez, C García… - Laboratory …, 2002 - Elsevier
Abstract Knowledge about the molecular mechanisms involved in the pathogenesis of
tumoral progression in mycosis fungoides (MF) is still scarce. Because the 9p21 locus
seems to be a good target for a detailed study in MF, this prompted us to compare the
mechanisms of inactivation of the p16 INK4a, p15 INK4b, and p14 ARF genes in aggressive
and stable forms of MF, performing microsatellite analysis, methylation-specific polymerase
chain reaction, direct sequencing, and p16 INK4a protein expression by …