[PDF][PDF] Mycosis fungoides and Sezary syndrome

E Diamandidou, PR Cohen, R Kurzrock - Blood, 1996 - Citeseer
E Diamandidou, PR Cohen, R Kurzrock
Blood, 1996Citeseer
YCOSIS FUNGOIDES (MF) is an uncommon, indo-M lent T-cell lymphoma first described by
Alibert'in the early 1800s. It primarily involves the skin at early stages of the disease, with
plaques being the typical feature. After a variable period of time, it may progress with
development of cutaneous tumors and spread to visceral sites and lymph nodes (LNs).*
SBzary syndrome (SS) is an erythrodermic variant of NIF (MF) associated with the presence
of circulating tumor cells in the peripheral blood. Although MF/SS are often called cutaneous …
YCOSIS FUNGOIDES (MF) is an uncommon, indo-M lent T-cell lymphoma first described by Alibert'in the early 1800s. It primarily involves the skin at early stages of the disease, with plaques being the typical feature. After a variable period of time, it may progress with development of cutaneous tumors and spread to visceral sites and lymph nodes (LNs).* SBzary syndrome (SS) is an erythrodermic variant of NIF (MF) associated with the presence of circulating tumor cells in the peripheral blood. Although MF/SS are often called cutaneous T-cell lymphomas (CTCLs) they should be differentiated from other non-Hodgkin's lymphomas that involve the skin such as peripheral T-cell lymphomas and adult T-cell leukemid lymphomas. The diagnosis of MF rests on the clinical presentation as well as the histopathologic findings of an epidermotropic lymphoma with light microscopy showing a dermal infiltrate of lymphocytes with hyperconvoluted cerebriform nuclei and Pautrier's microabscesses. The malignant cells usually have a mature CD4'T-helper cell phenotype. Because of the heterogeneity of both clinical and pathologic patterns, the diagnosis of MF is often difficult to make.
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