Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation
CB Schmidt-Weber, K Blaser - Current opinion in immunology, 2004 - Elsevier
CB Schmidt-Weber, K Blaser
Current opinion in immunology, 2004•ElsevierTransforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside
and outside the immune system. Recent progress in this field underlines the role of TGF-β in
regulatory T (Treg) cells, where it participates in both suppression and differentiation. In
addition, recent information highlights the role of TGF-β in repair responses that lead to
matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as
asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β …
and outside the immune system. Recent progress in this field underlines the role of TGF-β in
regulatory T (Treg) cells, where it participates in both suppression and differentiation. In
addition, recent information highlights the role of TGF-β in repair responses that lead to
matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as
asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β …
Transforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-β in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-β in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β-mediated tissue remodelling can be a serious complication in such diseases.
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