[HTML][HTML] Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival
M Encinas, RJ Crowder, J Milbrandt… - Journal of Biological …, 2004 - ASBMB
The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) are neurotrophic
factors that influence several aspects of the developing and injured nervous system. GFLs
signal through a common receptor tyrosine kinase (Ret) and one of the four ligand-binding
co-receptors (GFRα1 to 4). Ligand-induced translocation of Ret to lipid rafts, where it
interacts with the nonreceptor tyrosine kinase Src, is a prerequisite for full biological activity
of these neurotrophic factors. This interaction and subsequent activation of Src are required …
factors that influence several aspects of the developing and injured nervous system. GFLs
signal through a common receptor tyrosine kinase (Ret) and one of the four ligand-binding
co-receptors (GFRα1 to 4). Ligand-induced translocation of Ret to lipid rafts, where it
interacts with the nonreceptor tyrosine kinase Src, is a prerequisite for full biological activity
of these neurotrophic factors. This interaction and subsequent activation of Src are required …