[HTML][HTML] Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2
L Bourgeois, M Brillard-Bourdet, D Deperthes… - Journal of Biological …, 1997 - ASBMB
The third human tissue kallikrein to be identified, hK2, could be an alternate or
complementary marker to kallikrein hK3 (prostate-specific antigen) for prostate diseases.
Most of the hK2 in seminal plasma forms an inactive complex with protein C inhibitor (PCI), a
serpin secreted by seminal vesicles. As serpin inhibitors behave as suicide substrates that
are cleaved early in the interaction with their target enzyme, and kallikreins have different
sensitivities to serpin inhibitors, we prepared a series of substrates with intramolecularly …
complementary marker to kallikrein hK3 (prostate-specific antigen) for prostate diseases.
Most of the hK2 in seminal plasma forms an inactive complex with protein C inhibitor (PCI), a
serpin secreted by seminal vesicles. As serpin inhibitors behave as suicide substrates that
are cleaved early in the interaction with their target enzyme, and kallikreins have different
sensitivities to serpin inhibitors, we prepared a series of substrates with intramolecularly …