Evolution of leukemic heterogeneity of human B-CLL lymphocytes between and within patients
GE Marti, GB Faguet, C Stewart, P Branham… - Mechanisms in B-Cell …, 1992 - Springer
GE Marti, GB Faguet, C Stewart, P Branham, PH Carter, GC Washington, P Bertin, J Muller…
Mechanisms in B-Cell Neoplasia 1992: Workshop at the National Cancer Institute …, 1992•SpringerB-chronic lymphocytic leukemia (B-CLL) is a disease manifested by the proliferation and
accumulation of a clone (s) of medium-sized lymphocytes with mature-appearing chromatin
and a characteristic surface immunophenotype. Monoclonality is usually evidenced by the
presence of a single heavy and light chain immunoglobulin and or a rearranged Ig gene (s).
The surface fluorescence intensity (FI) of membrane Ig is markedly diminished and
ineffective rearrangements are common. Typically patients fifty years of age or older present …
accumulation of a clone (s) of medium-sized lymphocytes with mature-appearing chromatin
and a characteristic surface immunophenotype. Monoclonality is usually evidenced by the
presence of a single heavy and light chain immunoglobulin and or a rearranged Ig gene (s).
The surface fluorescence intensity (FI) of membrane Ig is markedly diminished and
ineffective rearrangements are common. Typically patients fifty years of age or older present …
Abstract
B-chronic lymphocytic leukemia (B-CLL) is a disease manifested by the proliferation and accumulation of a clone(s) of medium-sized lymphocytes with mature-appearing chromatin and a characteristic surface immunophenotype. Monoclonality is usually evidenced by the presence of a single heavy and light chain immunoglobulin and or a rearranged Ig gene(s). The surface fluorescence intensity (FI) of membrane Ig is markedly diminished and ineffective rearrangements are common. Typically patients fifty years of age or older present with a stable, asymtomatic blood and marrow monoclonal B lymphocytosis. Blood lymphocytes may show considerable cytological or morphological variation between patients and within patients.
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