The fractional production rate of CLL lymphocytes, certainly in the peripheral blood and
possibly in the lymph nodes, is often lower than normal. On the other hand, the absolute
production ih CLL blood and in lymph nodes seems to be considerably increased in most
cases. Arguments for an increased lymphocyte life span in CLL, although fragmentary and
dispersed, exist. The blood CLL lymphocytes, as normal lymphocytes, exchange rapidly with
an extra vascular pool of lymphocytes. However, recirculation of lymphocytes—from blood to …