Familial reticuloendotheliosis with eosinophilia

GS Omenn - New England Journal of Medicine, 1965 - Mass Medical Soc
New England Journal of Medicine, 1965Mass Medical Soc
REPORTS of proliferative and infiltrative disorders of the reticuloendothelial system in
children have documented a fascinating and frustrating category of disease. Most of these
cases of multiorgan involvement and of unknown etiology have in common a proliferation of
histiocytes in the tissues and a lack of evidence of inheritance. 1, 2 However, several
families have been described in which 2 or more children have developed an illness
resembling the Letterer–Siwe syndrome. 3, 4 Whether this incidence represents genetic …
REPORTS of proliferative and infiltrative disorders of the reticuloendothelial system in children have documented a fascinating and frustrating category of disease. Most of these cases of multiorgan involvement and of unknown etiology have in common a proliferation of histiocytes in the tissues and a lack of evidence of inheritance.1 , 2 However, several families have been described in which 2 or more children have developed an illness resembling the Letterer–Siwe syndrome.3 , 4 Whether this incidence represents genetic transmission, common exposure to some environmental agent or organism or merely chance is unclear. No known family has been affected in more than 1 sibship.
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The New England Journal Of Medicine