[HTML][HTML] Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells
T Ogihara, BC Shin, M Anai, H Katagiri, K Inukai… - Journal of Biological …, 1997 - ASBMB
Insulin receptor substrate (IRS)-2 is structurally and functionally similar to IRS-1. Indeed,
stimulation with insulin or insulin-like growth factor I led to the rapid tyrosine phosphorylation
of both IRS-1 and IRS-2, which in turn activated phosphatidylinositol (PI) 3-kinase in L6 cells
and rat skeletal muscle. However, IRS-2 was rapidly dephosphorylated (3–10 min after the
addition of insulin/insulin-like growth factor I), whereas IRS-1 phosphorylation continued for
at least 60 min. The time courses of the PI 3-kinase activity associated with IRS-1 and IRS-2 …
stimulation with insulin or insulin-like growth factor I led to the rapid tyrosine phosphorylation
of both IRS-1 and IRS-2, which in turn activated phosphatidylinositol (PI) 3-kinase in L6 cells
and rat skeletal muscle. However, IRS-2 was rapidly dephosphorylated (3–10 min after the
addition of insulin/insulin-like growth factor I), whereas IRS-1 phosphorylation continued for
at least 60 min. The time courses of the PI 3-kinase activity associated with IRS-1 and IRS-2 …