[HTML][HTML] Recruitment of multiple interferon regulatory factors and histone acetyltransferase to the transcriptionally active interferon a promoters
WC Au, PM Pitha - Journal of Biological Chemistry, 2001 - ASBMB
Type I interferon (IFN) plays a critical role in the innate immunity against viral infection.
Expression of IFNA genes in infected cells is cell type-dependent and is regulated at the
transcriptional level. The present study is focused on the molecular mechanism underlying
the differential expression of human IFNA1 and A2 genes. Two nucleotides, at positions− 98
and− 81 of IFNA1 and A2 promoter, were pivotal to the differential expression. The DNA pull-
down and chromatin precipitation assays have shown that nuclear interferon regulatory …
Expression of IFNA genes in infected cells is cell type-dependent and is regulated at the
transcriptional level. The present study is focused on the molecular mechanism underlying
the differential expression of human IFNA1 and A2 genes. Two nucleotides, at positions− 98
and− 81 of IFNA1 and A2 promoter, were pivotal to the differential expression. The DNA pull-
down and chromatin precipitation assays have shown that nuclear interferon regulatory …