The role of cationic antimicrobial peptides in innate host defences
REW Hancock, G Diamond - Trends in microbiology, 2000 - cell.com
Trends in microbiology, 2000•cell.com
Cationic antimicrobial peptides are found in all living species. A single animal can contain>
24 different antimicrobial peptides, which fall into four structural classes. These peptides are
produced in large quantities at sites of infection and/or inflammation and can have broad-
spectrum antibacterial, antifungal, antiviral, antiprotozoan and antisepsis properties. In
addition, they interact directly with host cells to modulate the inflammatory process and
innate defences.
24 different antimicrobial peptides, which fall into four structural classes. These peptides are
produced in large quantities at sites of infection and/or inflammation and can have broad-
spectrum antibacterial, antifungal, antiviral, antiprotozoan and antisepsis properties. In
addition, they interact directly with host cells to modulate the inflammatory process and
innate defences.
Abstract
Cationic antimicrobial peptides are found in all living species. A single animal can contain >24 different antimicrobial peptides, which fall into four structural classes. These peptides are produced in large quantities at sites of infection and/or inflammation and can have broad-spectrum antibacterial, antifungal, antiviral, antiprotozoan and antisepsis properties. In addition, they interact directly with host cells to modulate the inflammatory process and innate defences.
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