[HTML][HTML] Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction …
J Guay, K Bateman, R Gordon, J Mancini… - Journal of Biological …, 2004 - ASBMB
Peripheral inflammation involves an increase in cyclooxygenase-2 (COX-2)-mediated
prostaglandin (PG) synthesis in the central nervous system (CNS), which contributes to
allodynia and hyperalgesia. In the present study we have determined the changes in
prostanoid tissue levels and in expression of terminal prostanoid synthases in both the CNS
and inflamed peripheral tissue during carrageenan-induced paw inflammation in the rat.
Prostanoid levels were measured by liquid chromatography-mass spectrometry and enzyme …
prostaglandin (PG) synthesis in the central nervous system (CNS), which contributes to
allodynia and hyperalgesia. In the present study we have determined the changes in
prostanoid tissue levels and in expression of terminal prostanoid synthases in both the CNS
and inflamed peripheral tissue during carrageenan-induced paw inflammation in the rat.
Prostanoid levels were measured by liquid chromatography-mass spectrometry and enzyme …