Localization of cyclooxygenase-2 and prostaglandin E2 receptor EP3 in the rat lumbar spinal cord
F Beiche, T Klein, R Nüsing, W Neuhuber… - Journal of …, 1998 - Elsevier
Cyclooxygenase-2 (COX-2) is now considered to be the major constitutively expressed COX
isozyme in the central nervous system. The present immunocytochemical study details
localization of COX-2 immunoreactivity in rat spinal cord along with the expression of
prostaglandin E2 receptor subtype EP3. Prominent COX-2 staining was observed in the
nuclear envelope of neurons throughout the spinal cord, especially in the superficial dorsal
horn laminae and motoneurons of lamina IX, as well as in glial cells of the white matter …
isozyme in the central nervous system. The present immunocytochemical study details
localization of COX-2 immunoreactivity in rat spinal cord along with the expression of
prostaglandin E2 receptor subtype EP3. Prominent COX-2 staining was observed in the
nuclear envelope of neurons throughout the spinal cord, especially in the superficial dorsal
horn laminae and motoneurons of lamina IX, as well as in glial cells of the white matter …