[HTML][HTML] Nerve growth factor activation of Erk-1 and Erk-2 induces matrix metalloproteinase-9 expression in vascular smooth muscle cells
KMF Khan, DJ Falcone, R Kraemer - Journal of Biological Chemistry, 2002 - ASBMB
In response to vascular injury, smooth muscle cells migrate from the media into the intima,
where they contribute to the development of neointimal lesions. Increased matrix
metalloproteinase (MMP) expression contributes to the migratory response of smooth
muscle cells by releasing them from their surrounding extracellular matrix. MMPs may also
participate in the remodeling of extracellular matrix in vascular lesions that could lead to
plaque weakening and subsequent rupture. Neurotrophins and their receptors, the Trk …
where they contribute to the development of neointimal lesions. Increased matrix
metalloproteinase (MMP) expression contributes to the migratory response of smooth
muscle cells by releasing them from their surrounding extracellular matrix. MMPs may also
participate in the remodeling of extracellular matrix in vascular lesions that could lead to
plaque weakening and subsequent rupture. Neurotrophins and their receptors, the Trk …