Protective effect of heme oxygenase induction in ischemic acute renal failure
H Shimizu, T Takahashi, T Suzuki… - Critical care …, 2000 - journals.lww.com
Objective: To examine the role of heme oxygenase-1 (HO-1) induction in the recovery of
renal function in rats with ischemic acute renal failure. Design: Randomized, masked,
controlled animal study. Setting: University-based animal research facility. Subjects:
Sprague-Dawley male rats, weighing 200-250 g. Interventions: Anesthetized rats were
subjected to bilateral flank incisions, and the right kidney was removed. Renal ischemia was
performed by left renal microvascular clamping, followed by reflow of the blood …
renal function in rats with ischemic acute renal failure. Design: Randomized, masked,
controlled animal study. Setting: University-based animal research facility. Subjects:
Sprague-Dawley male rats, weighing 200-250 g. Interventions: Anesthetized rats were
subjected to bilateral flank incisions, and the right kidney was removed. Renal ischemia was
performed by left renal microvascular clamping, followed by reflow of the blood …