Solution equilibria of enterobactin and metal-enterobactin complexes
LD Loomis, KN Raymond - Inorganic Chemistry, 1991 - ACS Publications
LD Loomis, KN Raymond
Inorganic Chemistry, 1991•ACS PublicationsThe stabilities of the ferric complexes of the stepwise hydrolysis products of enterobactin
havebeen investigated. By comparison of the linear trimer (the first hydrolysis product of the
cyclic trilactone enterobactin) with the parent compound, it is found that the exceptional
stabilityof ferric enterobactin versus ferric com-plexes of tris (catechol) analogues is one-
third enthalpic and two-thirds entropic in origin. Both the linear trimer and linear dimer
hydrolysis products are effective iron uptake mediators when compared with enterobactin …
havebeen investigated. By comparison of the linear trimer (the first hydrolysis product of the
cyclic trilactone enterobactin) with the parent compound, it is found that the exceptional
stabilityof ferric enterobactin versus ferric com-plexes of tris (catechol) analogues is one-
third enthalpic and two-thirds entropic in origin. Both the linear trimer and linear dimer
hydrolysis products are effective iron uptake mediators when compared with enterobactin …
Summary
The stabilities of the ferric complexes of the stepwise hydrolysis products of enterobactin havebeen investigated. By comparison of the linear trimer (the first hydrolysis product of the cyclic trilactone enterobactin) with the parent compound, it is found that the exceptional stabilityof ferric enterobactin versus ferric com-plexes of tris (catechol) analogues is one-third enthalpic and two-thirds entropic in origin. Both the linear trimer and linear dimer hydrolysis products are effective iron uptake mediators when compared with enterobactin.
Acknowledgment. This research was supported by NIH Grant AI 11744. An American Cancer Society fellowship (to DJE) is gratefully acknowledged.
ACS Publications