Publisher Summary This chapter discusses the role of free radicals and catalytic metal ions
in human disease. The importance of transition metal ions in mediating oxidant damage
naturally leads to the question as to what forms of such ions might be available to catalyze
radical reactions in vivo. The chapter discusses the metabolism of transition metals, such as
iron and copper. It also discusses the chelation therapy that is an approach to site-specific
antioxidant protection. The detection and measurement of lipid peroxidation is the evidence …