Cardiac energy metabolic shifts occur as a normal response to diverse physiologic and
dietary conditions and as a component of the pathophysiologic processes which accompany
cardiac hypertrophy, heart failure, and myocardial ischemia. The capacity to produce energy
via the utilization of fats by the mammalian postnatal heart is controlled in part at the level of
expression of nuclear genes encoding enzymes involved in mitochondrial fatty acid β-
oxidation (FAO). The principal transcriptional regulator of FAO enzyme genes is the …