[HTML][HTML] A polymorphic autoregulatory hormone response element in the human estrogen-related receptor α (ERRα) promoter dictates peroxisome proliferator …
J Laganiere, GB Tremblay, CR Dufour, S Giroux… - Journal of Biological …, 2004 - ASBMB
The orphan nuclear estrogen-related receptor α (ERRα) and transcriptional cofactor
peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) are involved in the
regulation of energy metabolism. Recently, extensive cross-talk between PGC-1α and ERRα
has been demonstrated. The presence of PGC-1α is associated with an elevated expression
of ERRα, and the two proteins can influence the transcriptional activities of one another.
Using a candidate gene approach to detect regulatory variants within genes encoding …
peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) are involved in the
regulation of energy metabolism. Recently, extensive cross-talk between PGC-1α and ERRα
has been demonstrated. The presence of PGC-1α is associated with an elevated expression
of ERRα, and the two proteins can influence the transcriptional activities of one another.
Using a candidate gene approach to detect regulatory variants within genes encoding …