[HTML][HTML] A role for peroxisome proliferator-activated receptor α (PPARα) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased …
FM Campbell, R Kozak, A Wagner, JY Altarejos… - Journal of Biological …, 2002 - ASBMB
Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor transcription
factor that has an important role in controlling cardiac metabolic gene expression. We
determined whether mice lacking PPARα (PPARα (−/−) mice) have alterations in cardiac
energy metabolism. Rates of palmitate oxidation were significantly decreased in isolated
working hearts from PPARα (−/−) hearts compared with hearts from age-matched wild type
mice (PPARα (+/+) mice),(62±12versus 154±65 nmol/g dry weight/min, respectively, p< …
factor that has an important role in controlling cardiac metabolic gene expression. We
determined whether mice lacking PPARα (PPARα (−/−) mice) have alterations in cardiac
energy metabolism. Rates of palmitate oxidation were significantly decreased in isolated
working hearts from PPARα (−/−) hearts compared with hearts from age-matched wild type
mice (PPARα (+/+) mice),(62±12versus 154±65 nmol/g dry weight/min, respectively, p< …