[HTML][HTML] The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor α (ERRα)

SN Schreiber, D Knutti, K Brogli, T Uhlmann… - Journal of Biological …, 2003 - ASBMB
The estrogen-related receptor α (ERRα) is one of the first orphan nuclear receptors
identified. Still, we know little about the mechanisms that regulate its expression and its
activity. In this study, we show that the transcriptional coactivator PGC-1, which is implicated
in the control of energy metabolism, regulates ERRα at two levels. First, PGC-1 induces the
expression of ERRα. Consistent with this induction, levels of ERRα mRNA in vivo are
highest in PGC-1 expressing tissues, such as heart, kidney, and muscle, and up-regulated in …