Reciprocal modulation of mitogen-activated protein kinases and mitogen-activated protein kinase phosphatase 1 and 2 in failing human myocardium
C Communal, WS Colucci, A Remondino… - Journal of Cardiac …, 2002 - Elsevier
Background: Mitogen-activated protein kinases (MAPKs), consisting of the ERK1/2, JNKs,
and p38-kinase families, play a key role in the regulation of myocyte growth and apoptosis in
vitro. The activity of MAPKs is regulated by dual-specificity MAPK phosphatases (MKPs).
Because myocardial failure is associated with myocyte hypertrophy and apoptosis, MAPKs
may play a pathophysiologic role in human myocardial failure. Methods and Results: We
measured MAPKs activities and the protein levels of MAPKs and MKPs (MKP-1 and MKP-2) …
and p38-kinase families, play a key role in the regulation of myocyte growth and apoptosis in
vitro. The activity of MAPKs is regulated by dual-specificity MAPK phosphatases (MKPs).
Because myocardial failure is associated with myocyte hypertrophy and apoptosis, MAPKs
may play a pathophysiologic role in human myocardial failure. Methods and Results: We
measured MAPKs activities and the protein levels of MAPKs and MKPs (MKP-1 and MKP-2) …