Reactive oxygen species (ROS) have been implicated in the pathogenesis of many clinical
disorders such as adult respiratory distress syndrome, ischemia-reperfusion injury,
atherosclerosis, neurodegenerative diseases, and cancer. Genetically engineered animal
models have been used as a tool for understanding the function of various antioxidant
enzymes in cellular defense mechanisms against various types of oxidant tissue injury.
Transgenic mice overexpressing three isoforms of superoxide dismutase, catalase, and the …