Paradigms and pitfalls of yeast longevity research
DA Sinclair - Mechanisms of ageing and development, 2002 - Elsevier
Over the past 10 years, considerable progress has been made in the yeast aging field.
Multiple lines of evidence indicate that a cause of yeast aging stems from the inherent
instability of repeated ribosomal DNA (rDNA). Over 16 yeast longevity genes have now been
identified and the majority of these have been found to affect rDNA silencing or stability.
Environmental conditions such as calorie restriction have been shown to modulate this
mode of aging via Sir2, an NAD-dependent histone deacetylase (HDAC) that binds at the …
Multiple lines of evidence indicate that a cause of yeast aging stems from the inherent
instability of repeated ribosomal DNA (rDNA). Over 16 yeast longevity genes have now been
identified and the majority of these have been found to affect rDNA silencing or stability.
Environmental conditions such as calorie restriction have been shown to modulate this
mode of aging via Sir2, an NAD-dependent histone deacetylase (HDAC) that binds at the …