[HTML][HTML] Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes
S Cormier-Regard, SV Nguyen… - Journal of Biological …, 1998 - ASBMB
Adrenomedullin is a recently discovered hypotensive peptide that is expressed in a variety
of cell and tissue types. Using the technique of differential display, the adrenomedullin gene
was observed to be differentially expressed in developing rat heart. Reverse transcription-
polymerase chain reaction analysis revealed that the level of adrenomedullin mRNA was
significantly higher in adult ventricular cardiac muscle as compared with embryonic day 17
ventricular cardiac muscle. Adrenomedullin receptor mRNA was constitutively expressed …
of cell and tissue types. Using the technique of differential display, the adrenomedullin gene
was observed to be differentially expressed in developing rat heart. Reverse transcription-
polymerase chain reaction analysis revealed that the level of adrenomedullin mRNA was
significantly higher in adult ventricular cardiac muscle as compared with embryonic day 17
ventricular cardiac muscle. Adrenomedullin receptor mRNA was constitutively expressed …