Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
WC Knowler, E Barrett-Connor, SE Fowler… - 2002 - jdc.jefferson.edu
BACKGROUND: Type 2 diabetes affects approximately 8 percent of adults in the United
States. Some risk factors--elevated plasma glucose concentrations in the fasting state and
after an oral glucose load, overweight, and a sedentary lifestyle--are potentially reversible.
We hypothesized that modifying these factors with a lifestyle-intervention program or the
administration of metformin would prevent or delay the development of diabetes. METHODS:
We randomly assigned 3234 nondiabetic persons with elevated fasting and post-load …
States. Some risk factors--elevated plasma glucose concentrations in the fasting state and
after an oral glucose load, overweight, and a sedentary lifestyle--are potentially reversible.
We hypothesized that modifying these factors with a lifestyle-intervention program or the
administration of metformin would prevent or delay the development of diabetes. METHODS:
We randomly assigned 3234 nondiabetic persons with elevated fasting and post-load …
[HTML][HTML] Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
Diabetes Prevention Program … - New England journal of …, 2002 - Mass Medical Soc
Background Type 2 diabetes affects approximately 8 percent of adults in the United States.
Some risk factors—elevated plasma glucose concentrations in the fasting state and after an
oral glucose load, overweight, and a sedentary lifestyle—are potentially reversible. We
hypothesized that modifying these factors with a lifestyle-intervention program or the
administration of metformin would prevent or delay the development of diabetes. Methods
We randomly assigned 3234 nondiabetic persons with elevated fasting and post-load …
Some risk factors—elevated plasma glucose concentrations in the fasting state and after an
oral glucose load, overweight, and a sedentary lifestyle—are potentially reversible. We
hypothesized that modifying these factors with a lifestyle-intervention program or the
administration of metformin would prevent or delay the development of diabetes. Methods
We randomly assigned 3234 nondiabetic persons with elevated fasting and post-load …