[CITATION][C] 23. Antibodies to Tamm-Horsfall Urinary Glycoprotein in Patients with Urinary Tract Infection, Reflux Nephropathy, Urinary Obstruction and Paraplegia

KL Lynn, RR Bailey, A Groufsky, JS Hunt… - Reflux Nephropathy …, 1984 - karger.com
KL Lynn, RR Bailey, A Groufsky, JS Hunt, AR Bean, AR McGiven
Reflux Nephropathy Update: 1983, 1984karger.com
Tamm-Horsfall urinary glycoprotein (THP) is produced by, and associated with, a discrete
segment of the distal renal tubule [1] and is the most abundant protein of renal origin in
normal urine [2]. Hodson et al.[3] suggested that antibodies to THP could be formed in
patients with reflux nephropathy (RN) and that their detection might prove a marker of the
condition. Fasth et al.[4], however, did not find increased titres of anti-THP antibodies in
schoolgirls with asymptomatic bacteriuria and vesico-ureteric reflux (VUR). Increased titres …
Tamm-Horsfall urinary glycoprotein (THP) is produced by, and associated with, a discrete segment of the distal renal tubule [1] and is the most abundant protein of renal origin in normal urine [2]. Hodson et al.[3] suggested that antibodies to THP could be formed in patients with reflux nephropathy (RN) and that their detection might prove a marker of the condition. Fasth et al.[4], however, did not find increased titres of anti-THP antibodies in schoolgirls with asymptomatic bacteriuria and vesico-ureteric reflux (VUR). Increased titres of anti-THP antibodies have been described in children [5] and adults [6, 7] with urinary tract infection (UTI), with or without VUR.
Interstitial deposits of THP have been found in RN, obstructive uropathy and other tubulo-interstitial disease [8, 9]. The suggestion that THP might be involved in the pathogenesis of renal diseases, such as RN, has been supported by the production of tubulo-interstitial nephritis in rats given autologous THP intradermally [10] and rabbits challenged with autologous urine or THP [11],
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