[HTML][HTML] Interaction of CArG elements and a GC-rich repressor element in transcriptional regulation of the smooth muscle myosin heavy chain gene in vascular smooth …
CS Madsen, CP Regan, GK Owens - Journal of Biological Chemistry, 1997 - ASBMB
We have previously shown that maximal expression of the rat smooth muscle myosin heavy
chain (SM-MHC) gene in cultured rat aortic smooth muscle cells (SMCs) required the
presence of a highly conserved domain (nucleotides− 1321 and− 1095) that contained two
positive-acting serum response factor (SRF) binding elements (CArG boxes 1 and 2) and a
negative-acting GC-rich element that was recognized by Sp1 (Madsen, CS, Hershey, JC,
Hautmann, MB, White, SL, and Owens, GK (1997) J. Biol. Chem. 272, 6332–6340). In this …
chain (SM-MHC) gene in cultured rat aortic smooth muscle cells (SMCs) required the
presence of a highly conserved domain (nucleotides− 1321 and− 1095) that contained two
positive-acting serum response factor (SRF) binding elements (CArG boxes 1 and 2) and a
negative-acting GC-rich element that was recognized by Sp1 (Madsen, CS, Hershey, JC,
Hautmann, MB, White, SL, and Owens, GK (1997) J. Biol. Chem. 272, 6332–6340). In this …