[HTML][HTML] Positive-and negative-acting Krüppel-like transcription factors bind a transforming growth factor β control element required for expression of the smooth …
PJ Adam, CP Regan, MB Hautmann… - Journal of Biological …, 2000 - ASBMB
Transforming growth factor β (TGF-β) is implicated in the regulation of smooth muscle cell
(SMC) differentiation. We previously identified a novel TGF-β control element (TCE) in the
promoters of SMC differentiation marker genes, including α-smooth muscle actin and
SM22α. In this study, the importance of the TCE in regulation of SM22α gene expressionin
vivo was investigated by mutating it within the context of a mouse SM22α promoter-lacZ
transgenic construct. Mutation of the TCE completely abolished SM22α promoter activity in …
(SMC) differentiation. We previously identified a novel TGF-β control element (TCE) in the
promoters of SMC differentiation marker genes, including α-smooth muscle actin and
SM22α. In this study, the importance of the TCE in regulation of SM22α gene expressionin
vivo was investigated by mutating it within the context of a mouse SM22α promoter-lacZ
transgenic construct. Mutation of the TCE completely abolished SM22α promoter activity in …