[HTML][HTML] Muscle specificity encoded by specific serum response factor-binding sites
PS Chang, L Li, J McAnally, EN Olson - Journal of Biological Chemistry, 2001 - ASBMB
Serum response factor (SRF) is a MADS box transcription factor that regulates muscle-
specific and growth factor-inducible genes by binding the consensus sequence CC (A/T) 6
GG, known as a CArG box. Because SRF expression is not restricted solely to muscle, its
expression alone cannot account for the muscle specificity of some of its target genes. To
understand further the role of SRF in muscle-specific transcription, we created transgenic
mice harboring lacZ transgenes linked to tandem copies of different CArG boxes with …
specific and growth factor-inducible genes by binding the consensus sequence CC (A/T) 6
GG, known as a CArG box. Because SRF expression is not restricted solely to muscle, its
expression alone cannot account for the muscle specificity of some of its target genes. To
understand further the role of SRF in muscle-specific transcription, we created transgenic
mice harboring lacZ transgenes linked to tandem copies of different CArG boxes with …