Toll-like receptors: mammalian 'taste receptors' for a smorgasbord of microbial invaders
PA Sieling, RL Modlin - Current opinion in microbiology, 2002 - Elsevier
PA Sieling, RL Modlin
Current opinion in microbiology, 2002•ElsevierIn Drosophila, the Toll family of proteins is responsible for the recognition of bacteria and
fungi. In mammals, Toll-like receptors (TLRs) are able to recognize and respond to microbial
pathogens. Recent findings have defined the relationship between many TLRs and their
microbial ligands, as well as the effect of TLR ligation on host defense. These findings have
also provided a framework for determining how TLRs may by used to therapeutically
modulate immune responses to infection.
fungi. In mammals, Toll-like receptors (TLRs) are able to recognize and respond to microbial
pathogens. Recent findings have defined the relationship between many TLRs and their
microbial ligands, as well as the effect of TLR ligation on host defense. These findings have
also provided a framework for determining how TLRs may by used to therapeutically
modulate immune responses to infection.
In Drosophila, the Toll family of proteins is responsible for the recognition of bacteria and fungi. In mammals, Toll-like receptors (TLRs) are able to recognize and respond to microbial pathogens. Recent findings have defined the relationship between many TLRs and their microbial ligands, as well as the effect of TLR ligation on host defense. These findings have also provided a framework for determining how TLRs may by used to therapeutically modulate immune responses to infection.
Elsevier