An integrated model of immunoregulation mediated by regulatory T cell subsets
H Jiang, L Chess - Advances in immunology, 2004 - Elsevier
Publisher Summary The immune system is capable of mounting effective immune responses
to a virtually infinite variety of foreign pathogens or tumor cells, while avoiding harmful
immune responses to self. This is achieved by central thymic selection and peripheral
regulation. It is clear that thymocytes expressing T cell receptors with high affinity for self-
peptide/MHC complexes undergo apoptosis and are deleted centrally in the thymus. Recent
experiments have highlighted the fact that central thymic negative selection eliminates the …
to a virtually infinite variety of foreign pathogens or tumor cells, while avoiding harmful
immune responses to self. This is achieved by central thymic selection and peripheral
regulation. It is clear that thymocytes expressing T cell receptors with high affinity for self-
peptide/MHC complexes undergo apoptosis and are deleted centrally in the thymus. Recent
experiments have highlighted the fact that central thymic negative selection eliminates the …