[HTML][HTML] Increased expression of the SNARE accessory protein Munc18c in lipid-mediated insulin resistance
IR Schlaepfer, LK Pulawa, LDMCB Ferreira… - Journal of lipid …, 2003 - ASBMB
Fatty acids inhibit insulin-mediated glucose metabolism in skeletal muscle, an effect largely
attributed to defects in insulin-mediated glucose transport. Insulin-resistant mice transgenic
for the overexpression of lipoprotein lipase (LPL) in skeletal muscle were used to examine
the molecular mechanism (s) in more detail. Using DNA gene chip array technology, and
confirmation by RT-PCR and Western analysis, increases in the yeast Sec1p homolog
Munc18c mRNA and protein were found in the gastrocnemius muscle of transgenic mice …
attributed to defects in insulin-mediated glucose transport. Insulin-resistant mice transgenic
for the overexpression of lipoprotein lipase (LPL) in skeletal muscle were used to examine
the molecular mechanism (s) in more detail. Using DNA gene chip array technology, and
confirmation by RT-PCR and Western analysis, increases in the yeast Sec1p homolog
Munc18c mRNA and protein were found in the gastrocnemius muscle of transgenic mice …