[HTML][HTML] Munc18-syntaxin complexes and exocytosis in human platelets

A Houng, J Polgar, GL Reed - Journal of Biological Chemistry, 2003 - ASBMB
The Sec1-Munc18 (SM) proteins are required for cellular exocytosis, but their mechanistic
function remains poorly understood. We examined SM-syntaxin complexes in human
platelets, which are terminally differentiated, anuclear cells that secrete the contents of their
intracellular granules through syntaxin 2-and syntaxin 4-dependent mechanisms. Munc18a,
Munc18b, and Munc18c were detected in human platelets by immunoblotting and/or PCR.
The SM proteins and syntaxin 2 were found in the membrane and cytosolic fractions of cells …