[HTML][HTML] Molecular Identification of Two Novel Munc-18 Isoforms Expressed in Non-neuronal Tissues (∗)
JT Tellam, S McIntosh, DE James - Journal of Biological Chemistry, 1995 - ASBMB
Munc-18, also known as n-Sec1 or rbSec1, is a syntaxin-binding protein thought to play a
role in regulating synaptic vesicle exocytosis. Although a gene family of syntaxins has been
identified, only a limited subset bind to Munc-18. This implicates the existence of other
mammalian Munc-18 homologues that may be involved in a range of vesicle transport
reactions. The purpose of the present study was to identify other members of the Munc-18
family by cDNA cloning. Three distinct Munc-18 isoforms, Munc-18a, previously identified in …
role in regulating synaptic vesicle exocytosis. Although a gene family of syntaxins has been
identified, only a limited subset bind to Munc-18. This implicates the existence of other
mammalian Munc-18 homologues that may be involved in a range of vesicle transport
reactions. The purpose of the present study was to identify other members of the Munc-18
family by cDNA cloning. Three distinct Munc-18 isoforms, Munc-18a, previously identified in …