Antibody regulation of B cell development
E Meffre, R Casellas, MC Nussenzweig - Nature immunology, 2000 - nature.com
E Meffre, R Casellas, MC Nussenzweig
Nature immunology, 2000•nature.comAntibodies on the surface of B lymphocytes trigger adaptive immune responses and control
a series of antigen-independent checkpoints during B cell development. These physiologic
processes are regulated by a complex of membrane immunoglobulin and two signal
transducing proteins known as Igα and Igβ. Here we focus on the role of antibodies in
governing the maturation of B cells from early antigen-independent through the final antigen-
dependent stages.
a series of antigen-independent checkpoints during B cell development. These physiologic
processes are regulated by a complex of membrane immunoglobulin and two signal
transducing proteins known as Igα and Igβ. Here we focus on the role of antibodies in
governing the maturation of B cells from early antigen-independent through the final antigen-
dependent stages.
Abstract
Antibodies on the surface of B lymphocytes trigger adaptive immune responses and control a series of antigen-independent checkpoints during B cell development. These physiologic processes are regulated by a complex of membrane immunoglobulin and two signal transducing proteins known as Igα and Igβ. Here we focus on the role of antibodies in governing the maturation of B cells from early antigen-independent through the final antigen-dependent stages.
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