[HTML][HTML] Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin
KE Bachman, MR Rountree, SB Baylin - Journal of Biological Chemistry, 2001 - ASBMB
We demonstrate that the recently identified DNA methyltransferases, Dnmt3a and Dnmt3b,
like DNMT1, repress transcription in a methylation-independent manner. Dnmt3a and
Dnmt3b repress transcription primarily through a plant homeodomain-like motif that is
shared with the ATRX protein but is not present in DNMT1. Unlike DNMT1, which localizes
to replication foci during S-phase in murine embryonic fibroblasts, Dnmt3a co-localizes with
heterochromatin protein 1 α (HP1α) and methyl-CpG binding proteins throughout the cell …
like DNMT1, repress transcription in a methylation-independent manner. Dnmt3a and
Dnmt3b repress transcription primarily through a plant homeodomain-like motif that is
shared with the ATRX protein but is not present in DNMT1. Unlike DNMT1, which localizes
to replication foci during S-phase in murine embryonic fibroblasts, Dnmt3a co-localizes with
heterochromatin protein 1 α (HP1α) and methyl-CpG binding proteins throughout the cell …