[HTML][HTML] Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation
TJ Kovacsovics, C Bachelot, A Toke, CJ Vlahos… - Journal of Biological …, 1995 - ASBMB
Platelet stimulation by thrombin leads to the activation of phosphoinositide 3-kinase (PI 3-K)
and to the production of the D3 phosphoinositides, phosphatidylinositol 3, 4-bisphosphate
(PdtIns-3, 4-P 2) and 3, 4, 5-trisphosphate (PdtIns-3, 4, 5-P 3). Because changes in the
levels of these phosphoinositides correlate with the kinetics of actin assembly, they have
been proposed to mediate actin assembly, causing cell shape changes. Wortmannin and
LY294002, two unrelated inhibitors of PI 3-K, were used to investigate the role of PI 3-K in …
and to the production of the D3 phosphoinositides, phosphatidylinositol 3, 4-bisphosphate
(PdtIns-3, 4-P 2) and 3, 4, 5-trisphosphate (PdtIns-3, 4, 5-P 3). Because changes in the
levels of these phosphoinositides correlate with the kinetics of actin assembly, they have
been proposed to mediate actin assembly, causing cell shape changes. Wortmannin and
LY294002, two unrelated inhibitors of PI 3-K, were used to investigate the role of PI 3-K in …