[HTML][HTML] Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling
SO Kim, J Jiang, W Yi, GS Feng, SJ Frank - Journal of Biological Chemistry, 1998 - ASBMB
Growth hormone (GH) signaling requires activation of the GH receptor (GHR)-associated
tyrosine kinase, JAK2. JAK2 activation by GH is believed to facilitate initiation of various
pathways including the Ras, mitogen-activated protein kinase, STAT, insulin receptor
substrate (IRS), and phosphatidylinositol 3-kinase systems. In the present study, we explore
the biochemical and functional involvement of the Src homology 2 (SH2)-containing protein-
tyrosine phosphatase, SHP-2, in GH signaling. GH stimulation of murine NIH 3T3-F442A …
tyrosine kinase, JAK2. JAK2 activation by GH is believed to facilitate initiation of various
pathways including the Ras, mitogen-activated protein kinase, STAT, insulin receptor
substrate (IRS), and phosphatidylinositol 3-kinase systems. In the present study, we explore
the biochemical and functional involvement of the Src homology 2 (SH2)-containing protein-
tyrosine phosphatase, SHP-2, in GH signaling. GH stimulation of murine NIH 3T3-F442A …