Regulated transport of the glucose transporter GLUT4

NJ Bryant, R Govers, DE James - Nature reviews Molecular cell biology, 2002 - nature.com
Nature reviews Molecular cell biology, 2002nature.com
In muscle and fat cells, insulin stimulates the delivery of the glucose transporter GLUT4 from
an intracellular location to the cell surface, where it facilitates the reduction of plasma
glucose levels. Understanding the molecular mechanisms that mediate this translocation
event involves integrating our knowledge of two fundamental processes—the signal
transduction pathways that are triggered when insulin binds to its receptor and the
membrane transport events that need to be modified to divert GLUT4 from intracellular …
Abstract
In muscle and fat cells, insulin stimulates the delivery of the glucose transporter GLUT4 from an intracellular location to the cell surface, where it facilitates the reduction of plasma glucose levels. Understanding the molecular mechanisms that mediate this translocation event involves integrating our knowledge of two fundamental processes — the signal transduction pathways that are triggered when insulin binds to its receptor and the membrane transport events that need to be modified to divert GLUT4 from intracellular storage to an active plasma membrane shuttle service.
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