Nuclear factor-κb in the liver of patients with chronic hepatitis c: Decreased rela expression is associated with enhanced fibrosis progression
The mechanisms of liver damage in chronic hepatitis C virus (HCV) infection are poorly
understood. The transcription factor, nuclear factor-κB (NF-κB), regulates the expression of
genes involved in apoptosis, inflammation, and antiviral response. It plays a protective role
in several forms of liver damage. In this study, we analyzed NF-κB by gel mobility shift assay
and immunohistochemistry in liver biopsies from HCV-infected patients, and we have
determined the hepatic levels of the components of the NF-κB system by semiquantitative …
understood. The transcription factor, nuclear factor-κB (NF-κB), regulates the expression of
genes involved in apoptosis, inflammation, and antiviral response. It plays a protective role
in several forms of liver damage. In this study, we analyzed NF-κB by gel mobility shift assay
and immunohistochemistry in liver biopsies from HCV-infected patients, and we have
determined the hepatic levels of the components of the NF-κB system by semiquantitative …