[PDF][PDF] Chromosomal assignment of two human B-raf (Rmil) proto-oncogene loci: B-raf-1 encoding the p94" and B-raf-2, a processed pseudogene
A Eychène, JV Barnier, F Apiou, B Dutrillauxº - Oncogene, 1992 - academia.edu
The B-raf gene is the human homolog of the avian c-Rmil proto-oncogene encoding a 94-
kDa serine/threo-nine kinase detected in avian cells. We have previously shown that this
protein contains amino-terminal sequences not found in other proteins of the mil/raf gene
family. These sequences are encoded by three exons in the avian genome. We report that
these three exons are conserved in the human B-raf gene and that they encode an amino
acid sequence similar to that of the avian c-Rmil gene, indicating that in both avian and …
kDa serine/threo-nine kinase detected in avian cells. We have previously shown that this
protein contains amino-terminal sequences not found in other proteins of the mil/raf gene
family. These sequences are encoded by three exons in the avian genome. We report that
these three exons are conserved in the human B-raf gene and that they encode an amino
acid sequence similar to that of the avian c-Rmil gene, indicating that in both avian and …