B-raf, a New Member of the raf Family, is Activated by DNA Rearrangement
S Ikawa, M Fukui, Y Ueyama, N Tamaoki… - … and cellular biology, 1988 - Taylor & Francis
S Ikawa, M Fukui, Y Ueyama, N Tamaoki, T Yamamoto, K Toyoshima
Molecular and cellular biology, 1988•Taylor & FrancisComplementary DNA clones of a putative transforming gene were isolated from NIH 3T3
cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is
related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal
portion of the normal B-raf protein confers transforming activity to the gene.
cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is
related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal
portion of the normal B-raf protein confers transforming activity to the gene.
Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.
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