[HTML][HTML] Interleukin-10 signaling blocks inhibitor of κB kinase activity and nuclear factor κB DNA binding
AJG Schottelius, MW Mayo, RB Sartor… - Journal of Biological …, 1999 - ASBMB
The transcription factor nuclear factor κB (NF-κB) coordinates the activation of numerous
genes in response to pathogens and proinflammatory cytokines and is, therefore, pivotal in
the development of acute and chronic inflammatory diseases. In its inactive state, NF-κB is
constitutively present in the cytoplasm as a p50-p65 heterodimer bound to its inhibitory
protein IκB. Proinflammatory cytokines, such as tumor necrosis factor (TNF), activate NF-κB
by stimulating the activity of the IκB kinases (IKKs) which phosphorylate IκBα on serine …
genes in response to pathogens and proinflammatory cytokines and is, therefore, pivotal in
the development of acute and chronic inflammatory diseases. In its inactive state, NF-κB is
constitutively present in the cytoplasm as a p50-p65 heterodimer bound to its inhibitory
protein IκB. Proinflammatory cytokines, such as tumor necrosis factor (TNF), activate NF-κB
by stimulating the activity of the IκB kinases (IKKs) which phosphorylate IκBα on serine …