Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin

RJ Ulevitch, PS Tobias - Annual review of immunology, 1995 - annualreviews.org
RJ Ulevitch, PS Tobias
Annual review of immunology, 1995annualreviews.org
Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin Page 1 Annu. Rev.
Immunol. 1995. 13:437-57 Copyright © 1995 by Annual Review.f Inc. All rights rmrved
RECEPTOR-DEPENDENT MECHANISMS OF CELL STIMULATION BY BACTERIAL
ENDOTOXIN RJ Ulevitch and PS Tobias Department ofImmunology, The Scripps Research
Institute, 10666 North Torrey Pines Road, La Jolla, California 92037 KEY WORDS: endotoxin,
CDI4, lipopolysaccharide binding protein, receptors, protein tyrosine phosphorylation ABSTRACT …
Abstract
In humans and experimental animals the presence of bacterial lipopolysaccha ride (endotoxin, LPS) signals the presence of gram-negative bacteria. Recogni tion of LPS triggers gene induction by myeloid and nonmyeloid lineage cells.
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