Adenosine-induced bronchoconstriction in asthma: role of mast cell-mediator release
MJ Cushley, ST Holgate - Journal of allergy and clinical immunology, 1985 - Elsevier
Adenosine, when it is administered by inhalation to asthmatic subjects, is a potent
bronchoconstrictor, although its mechanism of action is not known. Since adenosine has
been demonstrated to potentiate IgE-dependent mediator release from mast cells, we have
investigated the possible relationship between adenosine-induced bronchoconstriction and
release of mast cell mediators in 14 asthmatic subjects. In the first study the effect of the
putative mast cell-stabilizing drug cromolyn sodium (SCG) was observed on the dose …
bronchoconstrictor, although its mechanism of action is not known. Since adenosine has
been demonstrated to potentiate IgE-dependent mediator release from mast cells, we have
investigated the possible relationship between adenosine-induced bronchoconstriction and
release of mast cell mediators in 14 asthmatic subjects. In the first study the effect of the
putative mast cell-stabilizing drug cromolyn sodium (SCG) was observed on the dose …