Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas
MN Nikiforova, R Ciampi, G Salvatore, M Santoro… - Cancer letters, 2004 - Elsevier
MN Nikiforova, R Ciampi, G Salvatore, M Santoro, M Gandhi, JA Knauf, GA Thomas…
Cancer letters, 2004•ElsevierPoint mutations of the BRAF gene have been recently described with high prevalence in
papillary thyroid carcinomas. However, this molecular alteration has not been studied in
radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and
RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82
sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence
(4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements …
papillary thyroid carcinomas. However, this molecular alteration has not been studied in
radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and
RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82
sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence
(4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements …
Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.
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