Mechanism of vitamin D action and its regulation

AS Dusso, AJ Brown - American Journal of Kidney Diseases, 1998 - Elsevier
AS Dusso, AJ Brown
American Journal of Kidney Diseases, 1998Elsevier
Most of the biological actions of 1, 25 (OH) 2D3, the hormonal form of vitamin D, are
mediated by the vitamin D receptor (VDR), a member of the steroid/thyroid receptor
superfamily. The VDR functions as a ligand-induced transcription factor regulating the rate of
expression of genes involved not only in the control of calcium homeostasis and bone
remodeling, but also in immunomodulation, the control of hormone secretion, Inhibition of
cell growth, and induction of cell differentiation. This section discusses the molecular …
Most of the biological actions of 1,25(OH)2D3, the hormonal form of vitamin D, are mediated by the vitamin D receptor (VDR), a member of the steroid/thyroid receptor superfamily. The VDR functions as a ligand- induced transcription factor regulating the rate of expression of genes involved not only in the control of calcium homeostasis and bone remodeling, but also in immunomodulation, the control of hormone secretion, Inhibition of cell growth, and induction of cell differentiation. This section discusses the molecular mechanisms involved in the transcriptional control of gene expression by 1,25(OH)2D3. (Am J Kidney Dis 1998 Oct;32(2 Suppl 2):S13-24)
Elsevier