[HTML][HTML] Retinoid X receptor (RXR) ligands activate the human 25-hydroxyvitamin D3-24-hydroxylase promoter via RXR heterodimer binding to two vitamin D …
A Zou, MG Elgort, EA Allegretto - Journal of Biological Chemistry, 1997 - ASBMB
We have previously shown that RNA levels of kidney 25-hydroxyvitamin D 3-24-hydroxylase
(24 (OH) ase), a key metabolic enzyme for 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), is
up-regulated by retinoids in mice within hours. Deletion analysis of∼ 5500 base pairs of the
human 24 (OH) ase promoter showed that the sequence between− 316 and− 142 contained
the information necessary and sufficient for retinoid-induced activation of the promoter. This
region contains two previously defined vitamin D-responsive elements (VDREs) at− 294 to …
(24 (OH) ase), a key metabolic enzyme for 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), is
up-regulated by retinoids in mice within hours. Deletion analysis of∼ 5500 base pairs of the
human 24 (OH) ase promoter showed that the sequence between− 316 and− 142 contained
the information necessary and sufficient for retinoid-induced activation of the promoter. This
region contains two previously defined vitamin D-responsive elements (VDREs) at− 294 to …